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Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: pRICE cUBE
Date: August 11, 2017 02:05PM
[www.ksl.com]

Pigs may someday provide organs for human transplant surgeries, yet more than a few obstacles must be overcome first.

Using the genome-editing technology CRISPR, scientists deactivated a family of retroviruses within the pig genome overcoming a large hurdle in the path to the transplant of pig organs into humans.

Transplantation from one species to another — xenotransplantation — holds "great promise," the American and Chinese research team believes.

"Porcine organs are considered favorable resources for xenotransplantation since they are similar to human organs in size and function, and can be bred in large numbers," they wrote in a study published Thursday in the journal Science.

Retroviruses carry their genetic blueprint in the form of ribonucleic acid (or RNA) and transcribe this into deoxyribonucleic acid, commonly known as DNA. This is a reverse of the usual transcription process, which flows from DNA to RNA. This reversal makes it possible for retrovirus genes not only to infect cells but to become permanently incorporated into a cell's genome.

Dr. Ian McConnell, emeritus professor of veterinary science at the University of Cambridge, sees the research as a "promising first step." McConnell, who was not involved in the study, added that "it remains to be seen whether these results can be translated into a fully safe strategy in organ transplantation."

Formidable obstacles remain "in overcoming immunological rejection and physiological incompatibility of pig organs in humans," he said.

In August 2016, the US National Institutes of Health announced that it was considering a revision to its policy, introduced in 2009, guiding human-animal chimera research. A chimera is a single organism containing cells (and DNA) from two or more organisms.








Edited 1 time(s). Last edit at 08/11/2017 02:06PM by pRICE cUBE.
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Re: Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: mrbigstuff
Date: August 11, 2017 02:12PM
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Re: Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: cbelt3
Date: August 11, 2017 02:13PM
Animal valves have been transplanted into human patients for over 5 decades. However xenografts are primarily structural in nature, and have their antigens removed by aggressive chemical denaturing. This concept is a different take on the idea.
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Re: Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: mikebw
Date: August 11, 2017 02:26PM
Here's to pigs- The cause and solution to all of our problems!
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Re: Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: NewtonMP2100
Date: August 11, 2017 02:26PM
....this idea has been bacon [ bakin' ] for a long time now....



____________________________________________________

I reject your reality and substitute my own!
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Re: Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: GuyGene
Date: August 11, 2017 03:08PM
I don't know if I'll be able to eat bacon anymore



That old man - he don't think like no old man...
Now I wouldn't want to be within 400 - 500 yards of one of them nuclear bombs when it goes off! WW1 Vet Old Man
"He's pinned under an outcropping of rock. Lucky for him, the rock kept the dirt from burying him alive."
If idiots could fly, this place would be an airport. And I'd be a TSA agent.
A bonified member of The Mystic Knights of The Sea, George P. Stevens, President. Andy Brown, Treasurer, Algonquin J. Calhoun, Legal Consultant.
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Re: Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: pRICE cUBE
Date: August 11, 2017 03:19PM
Quote
GuyGene
I don't know if I'll be able to eat bacon anymore

It won't stop me.



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Re: Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: rgG
Date: August 11, 2017 03:43PM
Quote
pRICE cUBE
Quote
GuyGene
I don't know if I'll be able to eat bacon anymore

It won't stop me.

Lol.





Roswell, GA (Atlanta suburb)
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Re: Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: DP
Date: August 11, 2017 03:44PM
Quote
pRICE cUBE
Quote
GuyGene
I don't know if I'll be able to eat bacon anymore

It won't stop me.

thumbs up

Also, reading that CRISPR could be used to produce "designer babies".



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Re: Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: pRICE cUBE
Date: August 11, 2017 03:47PM
Quote
DP
Quote
pRICE cUBE
Quote
GuyGene
I don't know if I'll be able to eat bacon anymore

It won't stop me.

thumbs up

Also, reading that CRISPR could be used to produce "designer babies".


Will it also create CRISPR bacon?



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Re: Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: NewtonMP2100
Date: August 11, 2017 03:47PM
....the side effect is that you will have a yearning to be covered in blankets for the rest of your life [ pigs in a blanket, get it? ]......



____________________________________________________

I reject your reality and substitute my own!
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Re: Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: neophyte
Date: August 11, 2017 04:30PM
Calling the forum Rabbis: Will this be kosher?
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Re: Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: Bernie
Date: August 12, 2017 09:14AM
Calling the forum Imams: Will this be Halal?




Staunton, Virginia
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Re: Future Biotech: Will pigs supply organs to transplant and save human lives?
Posted by: Speedy
Date: August 12, 2017 09:55AM
I will believe it when I see it. The retroviri were a killer to the whole idea. Hard to believe they could engineer out all of them. (My daughter has chronic rejection in her kidney transplant and could really use a designer organ.)



Saint Cloud, Minnesota, where the weather is wonderful even when it isn't.
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