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Professor Didier Raoult, possible COVID 19 cure
Posted by: Undun
Date: March 19, 2020 12:07AM
Professor Raoult, in human trials, claims success with 24 patients using hydroxychloroquine. As it is a proven malaria treatment, it is known as being useable on humans without significant side effects.
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: freeradical
Date: March 19, 2020 12:22AM
Quote

Chloroquine has previously been used to prevent and treat malaria.
The drug was offered to 24 patients, who were among the first 24 to become infected in France’s southeastern region.
Patients were given the drug for 10 days. Researchers monitored the patients since the drug can cause severe side effects.
Raoult said those who did not receive the drug were still contagious after six days. Those who tried the drug were only 25% contagious, though.

[www.deseret.com]
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: Filliam H. Muffman
Date: March 19, 2020 01:08AM
It is a start. Not much information about incidence of side effects. The list of them is really, really long. It would be really nice to see a large study on how it works on people over the age of 60 that were put on respirators. I am a little surprised China has not published anything yet.



In tha 360. MRF User Map
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: Racer X
Date: March 19, 2020 01:52AM
this was brought up here a few days ago. very intrigued.

Let's be honest. How many of our modern meds have been derived from natural sources that mankind has been using for centuries in its more basic form?

Opiods, aspirin, penicillin, right off the bat.
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: Janit
Date: March 19, 2020 06:50AM
Quote
Racer X
this was brought up here a few days ago. very intrigued.

Let's be honest. How many of our modern meds have been derived from natural sources that mankind has been using for centuries in its more basic form?

Opiods, aspirin, penicillin, right off the bat.

Time to break out the gin and tonic.
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: Microman
Date: March 19, 2020 06:50AM
Is that the same med, that is mentioned in an episode of MASH?, The one where Klinger was taking it, but because of his middle eastern? decent, his red cells would change shape as in the African American (Black) disease that slips my mind at the moment..
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: MindMeld
Date: March 19, 2020 07:05AM
Quote
Microman
Is that the same med, that is mentioned in an episode of MASH?, The one where Klinger was taking it, but because of his middle eastern? decent, his red cells would change shape as in the African American (Black) disease that slips my mind at the moment..

Sickle cell anemia?
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: S. Pupp
Date: March 19, 2020 07:46AM
What could the mechanism be? It doesn't make sense to me that an anti-parasitic/anti-inflammatory would have any effect on a virus.
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: S. Pupp
Date: March 19, 2020 07:47AM
Quote
MindMeld
Quote
Microman
Is that the same med, that is mentioned in an episode of MASH?, The one where Klinger was taking it, but because of his middle eastern? decent, his red cells would change shape as in the African American (Black) disease that slips my mind at the moment..

Sickle cell anemia?

Sound more like hydroxyurea.
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: Janit
Date: March 19, 2020 08:10AM
Quote
MindMeld
Quote
Microman
Is that the same med, that is mentioned in an episode of MASH?, The one where Klinger was taking it, but because of his middle eastern? decent, his red cells would change shape as in the African American (Black) disease that slips my mind at the moment..

Sickle cell anemia?

Yes, probably, but it sounds like the MASH writers were confused about the actual interaction between chloroquine, malaria and sickle cell anemia. Klinger might also have had thalassemia, but that would be a confusion also. I would need to watch the episode to see just how confused they were.
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: pdq
Date: March 19, 2020 08:40AM
Klinger had G6PD deficiency. More common in those with middle eastern ancestry; leads to red cells breaking down in such patients, exacerbated by quinine antimalarials.
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: Janit
Date: March 19, 2020 09:21AM
Quote
pdq
Klinger had G6PD deficiency. More common in those with middle eastern ancestry; leads to red cells breaking down in such patients, exacerbated by quinine antimalarials.

Ah, thanks. G6PD deficiency, sickle cell anemia, and thalassemia all confer a degree of protection against malaria infections. Even though these genetic variants can cause anemias and other symptoms, they persist in areas where malaria is endemic because of this protection.
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: Bill in NC
Date: March 19, 2020 10:03AM
Quote
Undun
Professor Raoult, in human trials, claims success with 24 patients using hydroxychloroquine. As it is a proven malaria treatment, it is known as being useable on humans without significant side effects.

The above plus azithromycin seems to be the most effective drug regimen so far.
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: rjmacs
Date: March 19, 2020 10:20AM
Quote
Filliam H. Muffman
It is a start. Not much information about incidence of side effects. The list of them is really, really long. It would be really nice to see a large study on how it works on people over the age of 60 that were put on respirators. I am a little surprised China has not published anything yet.

China may well have run out of severe cases before being able to test this regimen...



rj
AKA
Vreemac, Moth of the Future
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: Wags
Date: March 19, 2020 11:39AM
China reported some success with this drug over a month ago.
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: numbered
Date: March 19, 2020 12:19PM
From the Wikipedia entry

Quote

Antiviral

Chloroquine has antiviral effects,[31] which works by increasing endosomal pH required for the virus/cell fusion process[32][33]

Chloroquine also seems to act as a zinc ionophore, thereby allowing extra cellular zinc to enter inside the cell and inhibit viral RNA dependant RNA polymerase. This could be the potential mechanism of action of chloroquine against COVID-19.[34][35]

Quote

COVID-19

For coronaviruses, chloroquine works by increasing endosomal pH and interfering with terminal glycosylation of the cellular receptor.[42][43] In late January 2020 during the 2019–20 coronavirus outbreak, Chinese medical researchers stated that exploratory research into chloroquine and two other medications, remdesivir and lopinavir/ritonavir, seemed to have "fairly good inhibitory effects" on the 2019 novel coronavirus. Requests to start clinical testing were submitted.[44][45][46] Chloroquine phosphate had been also proposed as a treatment for SARS-CoV with in vitro tests successfully inhibiting the virus.[47]

On 19 February 2020, preliminary results found that chloroquine may be effective and safe in treating COVID-19 associated pneumonia.[48][49] There is evidence to indicate the efficacy of chloroquine phosphate against SARS-CoV-2 in vitro on Vero cells.[50] The Guangdong Provincial Department of Science and Technology and the Guangdong Provincial Health and Health Commission issued a report stating that chloroquine phosphate "improves the success rate of treatment and shortens the length of patient’s hospital stay" and recommended it for patients diagnosed with mild, moderate and severe cases of novel coronavirus pneumonia.[51]

Chloroquine has been recommended by Chinese, South Korean and Italian health authorities for the treatment of COVID-19 [52][53][54]; however, these agencies have noted important contraindications for people with certain heart conditions, diabetes, etc.[55][56] In February 2020, both drugs were shown to effectively inhibit COVID-19 in vitro [57], but a further study concluded that hydroxychloroquine was more potent than chloroquine, with a more tolerable safety profile. [58] Preliminary results from a multicentric trial, announced in a press conference, suggested that chloroquine is effective and safe in treating COVID-19 associated pneumonia, "improving lung imaging findings, promoting a virus-negative conversion, and shortening the disease course."[59]

On 16 March 2020, an advisor to the French government on COVID-19, Professor Didier Raoult, announced that a trial involving 24 patients from the southeast of France supported the claim that chloroquine was an effective treatment.[60] A dosage of 600 mg of hydroxychloroquine was administered to these patients every day for 10 days. The drug appeared to be responsible for a "rapid and effective speeding up of their healing process, and a sharp decrease in the amount of time they remained contagious."[61] The study also suggested that taking chloroquine in combination with the antibiotic azithromycin, which is known to be effective against complications from bacterial lung disease, led to even better outcomes. Professor Raoult said the results showed there was "a spectacular reduction in the number of positive cases" with the combination therapy.[62] At six days, among patients given combination therapy, the percentage of those still carrying SARS-CoV-2 was no more than 5%.[63][64]

On Thursday, March 19, it was revealed on radio channel RTL that the treatment has been administered to patients at La Pitié Salpêtrière hospital in Paris and at other undisclosed hospitals on a "compassionate" basis. The hospital did not elaborate on the term. Treatments began on Friday, March 13. Seven days of treatment are required before effects can be safely monitored and assessed.[citation needed]

Also on Thursday, March 19, it was revealed during the White House virus task force press conference by Dr. Hahn, that "compassionate use" refers to allowing physicians to decide on a case by case basis to utilize an experimental drug that is still in clinical trials to be used to treat a patient.
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: August West
Date: March 19, 2020 09:34PM
Thanks for the info, numbered



“There comes a point where we need to stop just pulling people out of the river. We need to go upstream and find out why they’re falling in."
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Re: Professor Didier Raoult, possible COVID 19 cure
Posted by: Racer X
Date: March 21, 2020 01:46AM
Quote
Microman
Is that the same med, that is mentioned in an episode of MASH?, The one where Klinger was taking it, but because of his middle eastern? decent, his red cells would change shape as in the African American (Black) disease that slips my mind at the moment..

I know there was an episode where they needed either chloraquine or primoquine, and the other was shipped. One prevented malaria, but only the other treated it.
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