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weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: NewtonMP2100
Date: June 07, 2022 01:09PM
....seems to work well to lose weight for non-diabetes individuals....40% of participants....lost 1/4 of their body weight....


Overweight people lost 35 to 52 pounds on newly approved diabetes drug, study says

....A weekly dose of a medication recently approved by the US Food and Drug Administration to treat type 2 diabetes may help adults without diabetes lose weight as well, a new study found.

Tirzepatide, which is sold under the brand name Mounjaro, was studied in people without diabetes in three dosages: 5, 10 and 15 milligrams. Participants with obesity or who were overweight and took the 5-milligram dose lost an average of 35 pounds (16 killograms), those on the 10-milligram dose lost an average of 49 pounds (22 kilograms), and participants on the 15-milligram dose lost an average of 52 pounds (23.6 kilograms).

“Almost 40% of individuals lost a quarter of their body weight,” said coauthor Dr. Ania Jastreboff, codirector of the Yale Center for Weight Management in a briefing for the media.

“The data was quite impressive,” said Dr. Robert Gabbay, chief medical officer of the American Diabetes Association, who spoke to CNN from the ADA’s 82nd Scientific Sessions in New Orleans, where the study results were presented.

“The weight loss that they got in this study was even greater than what had been seen in the previous studies of people with diabetes,” Gabbay, who was not involved with the study, said.


“The middle range of weight loss for people in this new study was 49 pounds – 49 pounds is a lot,” he said. “It’s the range of weight loss that we typically think only possible through surgery.”

All in all, people without diabetes lost an average of 15% to 20.9% of their starting body weight over the course of the 72-week double-blinded, randomized clinical trial, which was published Saturday in The New England Journal of Medicine. Participants who got a placebo lost between 2.4% and 3.1% of their body weight, on average.

In comparison, studies on people with diabetes who used tirzepatide found they lost an average of 15% of their starting body weight, Gabbay said.

“This is a not uncommon observation,” he said. “The impact of previous weight loss medications are less effective in people with diabetes, and we honestly don’t know exactly why.”

However, the impact of tirzepatide on people with diabetes is still “profound,” Gabbay said, “providing much more than other tools that we’ve had.”

Self-injected dose
For the new study, weekly injections of tirzepatide were tested in more than 2,500 people without diabetes who had a body mass index (BMI) over 30 or who were over 27 BMI and had at least one weight-related health condition such as high blood pressure, high cholesterol or cardiovascular disease. A measure of a person’s height-to-weight ratio, a BMI of 25 or higher is considered overweight in adults.

At the start of the study, the participants had an average weight of 231 pounds (104.8 kilograms) and average BMI of 38.

Adults in the study injected themselves with tirzepatide or a placebo once a week, using “a small penlike device with a tiny, tiny needle,” Gabbay said. “The prick from that needle is less painful than, for example, people that prick their fingers to measure blood glucose.”

People in the study also received counseling sessions to help them stay on a healthy diet with a daily 500-calorie deficit, as well as at least 150 minutes of physical activity each week. While that certainly helped, it does not explain the magnitude of the weight loss seen in the study, Gabbay said.

“The kind of weight loss that we see when people exercise and change their calorie intake is somewhere in the order of 5% to 7%,” he said. “This study showed a profoundly greater weight loss, far above what we would imagine with lifestyle changes.”

The most common side effects reported were nausea, diarrhea and constipation. Between 2.6% and 7.1% of the participants discontinued treatment due to adverse events.

Mounjaro carries a boxed warning about thyroid tumors and should not be used by people with a family history of certain thyroid conditions.......




could be very..........promising..........?!



_____________________________________

I reject your reality and substitute my own!



Edited 5 time(s). Last edit at 06/07/2022 01:14PM by NewtonMP2100.
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: ztirffritz
Date: June 07, 2022 01:19PM
Who makes that drug?

EDIT: Eli Lilly Co. (LLY)



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Edited 1 time(s). Last edit at 06/07/2022 01:20PM by ztirffritz.
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: NewtonMP2100
Date: June 07, 2022 01:20PM
....The U.S. Food and Drug Administration (FDA) approved Mounjaro™ (tirzepatide) injection, Eli Lilly and Company's new once-weekly GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist indicated as an adjunct to diet....



_____________________________________

I reject your reality and substitute my own!



Edited 2 time(s). Last edit at 06/07/2022 01:21PM by NewtonMP2100.
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: $tevie
Date: June 07, 2022 01:26PM
Then in ten years we'll find out it's carcinogenic, or causes strokes, or is addictive, or something. I hope I'm wrong but weight loss medication seems to always end up dangerous.



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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: Paul F.
Date: June 07, 2022 01:32PM
Sign me up...



Paul F.
-----
A sword never kills anybody; it is a tool in the killer's hand. - Lucius Annaeus Seneca c. 5 BC - 65 AD
----
Good is the enemy of Excellent. Talent is not necessary for Excellence.
Persistence is necessary for Excellence. And Persistence is a Decision.

--

--

--
Eureka, CA
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: mrbigstuff
Date: June 07, 2022 01:58PM
Quote
$tevie
Then in ten years we'll find out it's carcinogenic, or causes strokes, or is addictive, or something. I hope I'm wrong but weight loss medication seems to always end up dangerous.

My exact first reaction. We love our medications in the good ol' pharmacy of usa.
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: N-OS X-tasy!
Date: June 07, 2022 02:00PM
Quote
$tevie
Then in ten years we'll find out it's carcinogenic, or causes strokes, or is addictive, or something.

Exactly why I avoid taking drugs of any kind to the greatest extent possible.



It is what it is.
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: rgG
Date: June 07, 2022 02:07PM
Quote
N-OS X-tasy!
Quote
$tevie
Then in ten years we'll find out it's carcinogenic, or causes strokes, or is addictive, or something.

Exactly why I avoid taking drugs of any kind to the greatest extent possible.

Right there with you.





Roswell, GA (Atlanta suburb)
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: anonymouse1
Date: June 07, 2022 02:14PM
Question is whether any hypothetical future maladies are offset by the immediate health gains from moving out of obesity.
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: Paul F.
Date: June 07, 2022 02:14PM
Quote
anonymouse1
Question is whether any hypothetical future maladies are offset by the immediate health gains from moving out of obesity.

Exactly...
Sign me up.



Paul F.
-----
A sword never kills anybody; it is a tool in the killer's hand. - Lucius Annaeus Seneca c. 5 BC - 65 AD
----
Good is the enemy of Excellent. Talent is not necessary for Excellence.
Persistence is necessary for Excellence. And Persistence is a Decision.

--

--

--
Eureka, CA
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: vision63
Date: June 07, 2022 03:21PM
Quote
mrbigstuff
Quote
$tevie
Then in ten years we'll find out it's carcinogenic, or causes strokes, or is addictive, or something. I hope I'm wrong but weight loss medication seems to always end up dangerous.

My exact first reaction. We love our medications in the good ol' pharmacy of usa.

At least you got to wear your skinny jeans.
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: freeradical
Date: June 07, 2022 03:45PM
Vicodin rules...
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: testcase
Date: June 07, 2022 04:01PM
Quote
Paul F.
Sign me up...


Ditto
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: macphanatic
Date: June 07, 2022 04:11PM
People will take this and continue to gorge on crap. Then they'll wonder why they're in such poor health. Can't fix stupid.
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: Filliam H. Muffman
Date: June 07, 2022 04:18PM
Indications are that it increases likelihood of thyroid cancers. Apparently a lower chance of necrotizing fasciitis compared to Jardiance.
Study: https: //clinicaltrials.gov/ct2/show/results/NCT03861039?view=results

Weekly self-injections sounds like the main thing keeping the average person from using it.



In tha 360. MRF User Map
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: rz
Date: June 07, 2022 05:01PM
Quote
Filliam H. Muffman
Weekly self-injections sounds like the main thing keeping the average person from using it.

That, and I think I heard it costs like $1K per dose. And once you go off it, the weight it likely to come back.
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: Ombligo
Date: June 07, 2022 06:35PM
Typical American's reaction - "Great, now I can eat more doughnuts and Big Macs and not worry about getting fat."



“No persons are more frequently wrong, than those who will not admit they are wrong.” -- François de La Rochefoucauld

"Those who cannot accept the past are condemned to revise it." -- Geo. Mathias
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: Racer X
Date: June 07, 2022 07:23PM
Quote
$tevie
Then in ten years we'll find out it's carcinogenic, or causes strokes, or is addictive, or something. I hope I'm wrong but weight loss medication seems to always end up dangerous.

fen-fen is a perfect example IIRC.

The thing is, I imagine, is the risk from the obesity worse than the risk from the drug. Lots of medical treatments are trade-offs.



********************************************
“A sword never kills anybody; it is a tool in the killer's hand.” Seneca the Younger

The police have no duty to respond. See Castle Rock v. Gonzales, 545 U.S. 748 (2005) or Warren v. District of Columbia[1] (444 A.2d. 1, D.C. Ct. of Ap. 1981)

Judge Lee wrote that “we cannot jettison our constitutional rights, even if the goal behind a law is laudable." 9th Circuit Court of Appeals

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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: NewtonMP2100
Date: June 07, 2022 07:33PM
......but the little blue pill worked out.....o.k..........



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I reject your reality and substitute my own!
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: Racer X
Date: June 07, 2022 08:21PM
Quote
NewtonMP2100
......but the little blue pill worked out.....o.k..........

once they worked out the wrinkles



********************************************
“A sword never kills anybody; it is a tool in the killer's hand.” Seneca the Younger

The police have no duty to respond. See Castle Rock v. Gonzales, 545 U.S. 748 (2005) or Warren v. District of Columbia[1] (444 A.2d. 1, D.C. Ct. of Ap. 1981)

Judge Lee wrote that “we cannot jettison our constitutional rights, even if the goal behind a law is laudable." 9th Circuit Court of Appeals

[www.youtube.com]
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: N-OS X-tasy!
Date: June 07, 2022 08:40PM
Quote
Racer X
Quote
NewtonMP2100
......but the little blue pill worked out.....o.k..........

once they worked out the wrinkles

The whole point of The Little Blue Pill is to work out the wrinkles. smiley-laughing001



It is what it is.
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: Speedy
Date: June 07, 2022 09:09PM
I am 100% in.

It’s an appetite suppressant (“Nah, I’ll pass on the seconds.”) and the 31 gauge needle used for sub-q injections is pretty small.

[www.medscape.com]

The $1k/month is probably cheaper for insurers than many of the effects of obesity. In fact, it’s in the ball park of insulin.



Saint Cloud, Minnesota, where the weather is wonderful even when it isn't.
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: Paul F.
Date: June 07, 2022 10:11PM
In case anyone is interested... with GoodRX discounts, a 4-pack of tirzepatide is $975... and the study was a 72 week (18 month) study... which would cost $17,500.



Paul F.
-----
A sword never kills anybody; it is a tool in the killer's hand. - Lucius Annaeus Seneca c. 5 BC - 65 AD
----
Good is the enemy of Excellent. Talent is not necessary for Excellence.
Persistence is necessary for Excellence. And Persistence is a Decision.

--

--

--
Eureka, CA
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Re: weight & see?!....new diabetes drug could be 'game changer' for obesity/weight loss....
Posted by: Bill in NC
Date: June 08, 2022 08:37AM
Quote
Speedy
I am 100% in.

It’s an appetite suppressant (“Nah, I’ll pass on the seconds.”) and the 31 gauge needle used for sub-q injections is pretty small.

[www.medscape.com]

The $1k/month is probably cheaper for insurers than many of the effects of obesity. In fact, it’s in the ball park of insulin.

Yeah, I'll happily pay out-of-pocket.

Contrave worked for me for awhile but the side effects eventually got me down to only 4 hours of sleep at night so I had to d/c it.



Edited 1 time(s). Last edit at 06/08/2022 08:37AM by Bill in NC.
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