Phenylephrine, the decongestant that replaced pseudoephedrine, may not be all that.

[www.nytimes.com]

Say it snot true!

the only thing it does is raise your blood pressure. my doc told me this years ago. my daughter, an er nurse, says they use it in the er to RAISE a persons blood pressure sometimes.

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"Defending your own life when in immediate danger to me is a basic right of each person. " Lemon Drop 11/17/2023 03:10 pm

Heller, 554 U.S. 570 (2008) Private citizens have the right under the Second Amendment to possess an ordinary type of weapon and use it for lawful, historically established situations such as self-defense in a home, even when there is no relationship to a local militia.

"The conclusion is thus inescapable that the history, concept, and wording of the second amendment to the Constitution of the United States, as well as its interpretation by every major commentator and court in the first half-century after its ratification, indicates that what is protected is an individual right of a private citizen to own and carry firearms in a peaceful manner." Right to Keep and Bear Arms: Report of the Subcommittee on the Constitution of the Committee on the Judiciary, United States Senate, Ninety-seventh Congress, Second Session. U.S. Government Printing Office. 1982. Digitized September 30, 2008.

From the NYSRPA v Bruen "Today, we decline to adopt that two-part approach. . . . Despite the popularity of this two-step approach, it is one step too many. Step one of the predominant framework is broadly consistent with Heller, which demands a test rooted in the Second Amendment's text, as informed by history."

No surprise there. When that switch was made everyone was saying the replacement was completely useless compared to the original.

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C(-)ris
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….that’s…..snot what I heard….

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I reject your reality and substitute my own!

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TheTominator
Say it snot true!

That brought a quick laugh here!



Edited 1 time(s). Last edit at 09/12/2023 02:51PM by SKYLANE.

I still have a bottle of the good stuff in case. Or for the apocalypse.

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Hurts like a bastid...

This is why real snot noses use meth.

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Anyone who’s tried it can tell you that.

This will solve a lot of headaches (not literally). PE was the starting ingredient for meth, and that’s why Sudafed typically ended up behind the counter in drug stores.

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pdq
This will solve a lot of headaches (not literally).

Literally.

Phenylephrine has no medicinal effects (and can't be used to make meth), but it has plenty of side-effects, including fatigue, nausea/vomiting, and migraine headaches.

Long since time it was pulled from the shelves.

Now, it's time to make Tylenol/acetaminophen/paracetamol prescription-only.

[en.wikipedia.org]

Due to the absence of controlled studies, most of the information about the long-term safety of paracetamol comes from observational studies. These indicate a consistent pattern of increased mortality as well as cardiovascular (stroke, myocardial infarction), gastrointestinal (ulcers, bleeding) and renal adverse effects with increased dose of paracetamol. Use of paracetamol is associated with 1.9 times higher risk of peptic ulcer. Those who take it regularly at a higher dose (more than 2–3 g daily) are at much higher risk (3.6–3.7 times) of gastrointestinal bleeding and other bleeding events. Meta-analyses suggest that paracetamol may increase the risk of kidney impairment by 23% and kidney cancer by 28%. Paracetamol is particularly dangerous to the liver in overdose, but even without overdose those who take this drug may develop acute liver failure requiring liver transplantation more frequently than the users of nonsteroidal anti-inflammatory drugs. Paracetamol slightly but significantly increases blood pressure and heart rate. The majority of observational studies suggests that, used chronically, it may increase the risk of developing hypertension, as confirmed in a prospective randomized confirmed trial. The risk is higher with the higher dose...

Paracetamol toxicity is the foremost cause of acute liver failure in the Western world, and accounts for most drug overdoses in the United States, the United Kingdom, Australia, and New Zealand. Paracetamol overdose results in more calls to poison control centers in the US than overdose of any other pharmacological substance. According to the FDA, in the United States, "56,000 emergency room visits, 26,000 hospitalizations, and 458 deaths per year [were] related to acetaminophen-associated overdoses during the 1990s. Within these estimates, unintentional acetaminophen overdose accounted for nearly 25% of the emergency department visits, 10% of the hospitalizations, and 25% of the deaths."

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I still buy the OG Sudafed. One red pill makes me less sick. Yeah, I’m on “the list”.

Tight, tight, tight!

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Hurts like a bastid...

Yep, not news. Should not even be sold.

Hi everyone,

Common knowledge for years. If you wanted a nasal decongestant medicine that works, you still needed to use a product with pseudoephedrine. That I need to go to the pharmacist and provide him/her my drivers license to get it is truly annoying.

Robert

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Lux Interior
Phenylephrine, the decongestant that replaced pseudoephedrine, may not be all that.

Why has it taken this long for this to come out? I gave up on Phenylephrine years ago; it is useless. i do the dance to get the real pseudoephedrine behind the counter. What a sham!

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If you want to fix our country, work with us in the states. statesproject.org

"Success isn't about how much money you make. It is about the difference you make in people's lives."--Michelle Obama

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graylocks

Quote
Lux Interior
Phenylephrine, the decongestant that replaced pseudoephedrine, may not be all that.

Why has it taken this long for this to come out? I gave up on Phenylephrine years ago; it is useless. i do the dance to get the real pseudoephedrine behind the counter. What a sham!

Why? Because FDA reviews of OTC medications are rare as long as they contain ingredients classed as first safe and secondly as effective. Phenylephrine is both, but the effectiveness as a decongestant is only when used nasally in a nasal spray. Taken orally it is of low to no effectiveness due to acting on the whole body instead of locally in the nasal passages.



Edited 1 time(s). Last edit at 09/13/2023 09:06AM by JoeH.

Misleading topic title. It was not FDA, but their advisory panel. Big difference. But yes, it is ineffective when taken orally.

doc has banned me from using the real Sudafed since last time it raised my blood pressure through the roof.