You can do that now in Mail under Tiger (at least for new messages).
In Mail->Preferences->Composing there's an item for "Send new mail from:".
Otherwise, the default for replies is the address the original was sent to.
Regardless, I look forward to Leopard and improvements everywhere. I suspect, however, that someone who took this long to switch to Tiger isn't going to be one of the first to update to Leopard.