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booster gold?!.....trial of third COVID booster shot......
Posted by: NewtonMP2100
Date: June 19, 2021 09:22PM
.......indicates that side effects are worse with third booster.....the study gave Moderna as the third shot.....regardless of what was given the first/2nd shots.....


A man who boosted his Pfizer COVID-19 vaccine with a shot from Moderna said his side effects were a 'little more severe' the third time round

Scientists in the US are starting a booster shot trial, giving fully vaccinated people another jab.

Participants are given a booster shot of the Moderna vaccine — whether they previously got 2 shots of an mRNA vaccine (from Pfizer or Moderna) or 1 adenovirus (J&J) shot.

One participant told Insider his booster dose of Moderna gave him similar side effects to his second Pfizer shot, but the third was "a little bit more severe."

......Virus expert Joseph Hyser has been fully vaccinated since the end of January, and he's not really worried that his COVID-19 protection from the Pfizer vaccine has waned much since then.

Yet, when he got an email last month asking if he'd be interested in getting a third dose booster shot — this time from Moderna — he did not hesitate to say yes.

The virologist at Baylor College of Medicine signed right up, and took the elevator down six floors to Baylor's Vaccine Research Center, where he offered up his arm for a third jab.

"Oooh I got boosted!" he remembered bragging to family and friends afterwards, who were nonplussed about his unique booster shot experience.

Perhaps they didn't realize that Hyser is one of the first Americans to participate in a groundbreaking COVID-19 mix-and-match study, aimed at assessing whether boosters work, and whether different COVID-19 shots are safe — and possibly more effective — when they're mixed together.

Though Hyser says he experienced "similar types of side effects" from both Moderna's and Pfizer's mRNA shots, he said the side effects were "a little bit more obvious with the Moderna."

Is it safe to mix shots from Moderna, Pfizer, and Johnson & Johnson?

This is not Hyser's first vaccine trial, he's been in studies of smallpox shots, anthrax vaccines, and annual flu jabs.

"I'm a dyed in the wool nerd, so I mean, of course I think that this is interesting," he said of the trial. "I like being involved in being a part of producing science and information for the world."

The study that he's now part of, funded by the National Institutes of Health, will evaluate mixing different coronavirus booster shots to assess whether they will be safe and effective for adults of all ages across the US.

For now, the study is boosting only with a single dose of Moderna's vaccine, whether participants' first shots were from Moderna, or from Pfizer or Johnson & Johnson — the other two US-authorized vaccines. Other combinations of the vaccines, and which order they're taken in, will be added in to the study later on.

Study participants will get routine blood draws (Hyser already had his first), and initial results could be ready within months.

A big question this study will explore is whether boosting people who've had J&J's one-shot adenovirus vaccine with Moderna's mRNA shot might make the performance similar. (J&J's vaccine did not protect as well against mild and moderate disease compared to Pfizer and Moderna's two dose mRNA regimens during clinical trials.)

"Is it because of the [vaccine] construct, or is it because of the one dose? We don't really have the answer to that," lead study researcher Dr. Robert Atmar, from the Vaccine Research Center at Baylor, told Insider of J&J's lower efficacy.

A day of chills, body aches, and ibuprofen after the 3rd dose

While Hyser's Moderna side effects were a little more intense, he said they faded with some ibuprofen and a day of rest.

"I did, for Pfizer, have a little bit of chills, a little bit of muscle ache, but nothing that prevented me from conducting my normal day to day activities," he said, remembering how the day after his second shot in January he did some work, went grocery shopping, and made a pot of chili.

"With the booster, it was a little bit more severe," he said, describing waking up the day afterwards feeling "like I had done a very rigorous gym workout," with chills and arm soreness like he'd gotten a "hard punch in the shoulder." He popped some ibuprofen, which helped ease the aches, and by the following day, he felt like himself again.

"Given the dramatic impact that [the coronavirus] has had on the world, as a scientist, it's actually really heartening that these clinical trials are still going on and the secondary and tertiary questions are still being asked," Hyser said, estimating that he'll make about $600 total (compensation for his time) over the course of this study.



third shot.......trial......?!



_____________________________________

I reject your reality and substitute my own!



Edited 1 time(s). Last edit at 06/19/2021 09:26PM by NewtonMP2100.
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Re: booster gold?!.....trial of third COVID booster shot......
Posted by: S. Pupp
Date: June 19, 2021 09:44PM
Worse than the second shot?
Damn!
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Re: booster gold?!.....trial of third COVID booster shot......
Posted by: RAMd®d
Date: June 19, 2021 11:09PM
"With the booster, it was a little bit more severe," he said, describing waking up the day afterwards feeling "like I had done a very rigorous gym workout," with chills and arm soreness like he'd gotten a "hard punch in the shoulder." He popped some ibuprofen, which helped ease the aches, and by the following day, he felt like himself again.


I could live with that.

Literally.

Having no side effects other than a slightly sore arm for a few hours, the about would be acceptable.

Unless Diana is explaining the details, my eye glaze over in reading the find details, so I may have missed what might happen if the third booster shot was Pfizer, to compliment my previous two rounds of Pfizer.

Or why Moderna was chosen as the booster.

At any rate I'd be OK with this, assuming to goes to plan.





Your boos mean nothing to me, I've seen what you cheer for.

Insisting on your rights without acknowledging your responsibilities isn’t freedom, it’s adolescence.

We are a government of laws, not men.

Everybody matters or nobody matters.

When a good man is hurt,
all who would be called good
must suffer with him.

You and I have memories longer than the road that stretches out ahead.

There is no safety for honest men except
by believing all possible evil of evil men.

We don’t do focus groups. They just ensure that you don’t offend anyone, and produce bland inoffensive products. —Sir Jonathan Ive

An armed society is a polite society.
And hope is a lousy defense.

You make me pull, I'll put you down.

I *love* SIGs. It's Glocks I hate.
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Re: booster gold?!.....trial of third COVID booster shot......
Posted by: JoeH
Date: June 20, 2021 12:50AM
Quote
S. Pupp
Worse than the second shot?
Damn!

That's my thought too! I just had my second Moderna dose a week and a half ago, it was a bit much.
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Re: booster gold?!.....trial of third COVID booster shot......
Posted by: Speedy
Date: June 20, 2021 06:16AM
No side effects for me except for minor soreness at the bottom injection site with my second dose of Moderna. I’ll gladly take a booster.



Saint Cloud, Minnesota, where the weather is wonderful even when it isn't.
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Re: booster gold?!.....trial of third COVID booster shot......
Posted by: PeterB
Date: June 20, 2021 08:35AM
I found that the Pfizer shots were, on the whole, MUCH less intense than the J&J, in terms of pain from the shot. I didn't notice too much in the way of side effects for either vaccine afterwards, except maybe a bit of headache/fatigue ... more so for the second Pfizer than either the first or the J&J, but again that strikes me as a fairly nonspecific response to any vaccination, so really not too bothersome... I just took it easy the day of the shot and the day after. The people who are having more serious reactions to these shots, I wonder if it's really the mRNA/substantive portion of the vaccine they're having a response to, so much as the carrier -- either the nanoparticles or some other component of the carrier.

I'm waiting to make a bit of an announcement on the forum here about the results I've gotten of some testing, which are turning out to be quite interesting...




Freya says, 'Hello from NOLA, baby!' (Laissez bon temps rouler!)



Edited 2 time(s). Last edit at 06/20/2021 08:38AM by PeterB.
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Re: booster gold?!.....trial of third COVID booster shot......
Posted by: Don C
Date: June 20, 2021 09:35PM
PeterB is now in the teaser business ... "stay tuned for updates"

Sounds good though so we'll be interested in the developments.
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Re: booster gold?!.....trial of third COVID booster shot......
Posted by: RAMd®d
Date: June 21, 2021 05:57AM
Watch this space...





Your boos mean nothing to me, I've seen what you cheer for.

Insisting on your rights without acknowledging your responsibilities isn’t freedom, it’s adolescence.

We are a government of laws, not men.

Everybody matters or nobody matters.

When a good man is hurt,
all who would be called good
must suffer with him.

You and I have memories longer than the road that stretches out ahead.

There is no safety for honest men except
by believing all possible evil of evil men.

We don’t do focus groups. They just ensure that you don’t offend anyone, and produce bland inoffensive products. —Sir Jonathan Ive

An armed society is a polite society.
And hope is a lousy defense.

You make me pull, I'll put you down.

I *love* SIGs. It's Glocks I hate.
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Re: booster gold?!.....trial of third COVID booster shot......
Posted by: Ombligo
Date: June 21, 2021 07:23AM
I think a lot of people skipped the second dose simply because they had heard media reports and how bad it could be. Given that, I expect getting people to take a third dose that may be even worse will be even harder.

discomfort vs possible death... yep, Americans will risk death.



“No persons are more frequently wrong, than those who will not admit they are wrong.”
-- François de La Rochefoucauld

Growing older is mandatory. Growing up is optional.
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Re: booster gold?!.....trial of third COVID booster shot......
Posted by: Acer
Date: June 21, 2021 11:35AM
OK, so we've heard from ONE guy who got a third dose? That's it?
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