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Remember when we were struggling to understand the basics of the new vaccines and there was talk of a DNA vaccine before those mRNA vaccines stole the headlines...?
Posted by: Sarcany
Date: August 21, 2021 11:38PM
[www.bbc.com]

India approves world's first DNA Covid vaccine

The three-dose ZyCoV-D vaccine prevented symptomatic disease in 66% of those vaccinated, according to an interim study quoted by the vaccine maker Cadila Healthcare.

...Cadila Healthcare said it had conducted the largest clinical trial for the vaccine in India so far, involving 28,000 volunteers in more than 50 centres.

This is also the first time, the firm claimed, a Covid-19 vaccine had been tested in young people in India - 1,000 people belonging to the 12-18 age group. The jab was found to be "safe and very well tolerated" in this age group.

The key third phase of clinical trials was conducted at the peak of the deadly second wave of the virus. The vaccine maker believes this reaffirmed the jab's "efficacy against the mutant strains", especially the highly infectious Delta variant.

...Like other vaccines, a DNA vaccine, once administered, teaches the body's immune system to fight the real virus.

ZyCoV-D uses plasmids or small rings of DNA, that contain genetic information, to deliver the jab between two layers of the skin.

The plasmids carry information to the cells to make the "spike protein", which the virus uses to latch on and enter human cells.

Most Covid-19 vaccines work by giving the body instructions to make a fragment of the spike protein so it can trigger a person's immune system to produce antibodies and teach itself to fight off the virus.

...ZyCov-D is also India's first needle-free Covid-19 jab.

It is administered with a disposable needle-free injector, which uses a narrow stream of the fluid to penetrate the skin and deliver the jab to the proper tissue.

...Scientists say DNA vaccines are relatively cheap, safe and stable.

They can also be stored at higher temperatures - 2 to 8C.

Cadila Healthcare claims that their vaccine had shown "good stability" at 25C for at least three months - this would help the vaccine to be transported and stored easily.




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Re: Remember when we were struggling to understand the basics of the new vaccines and there was talk of a DNA vaccine before those mRNA vaccines stole the headlines...?
Posted by: PeterB
Date: August 22, 2021 08:29AM
I think the fear of DNA vaccines is largely misplaced. The chance that some plasmid DNA interacts with *your* DNA is pretty damned low ... it's far more likely that your body will see the DNA as foreign (which it is!) and try to destroy it...




Freya says, 'Hello from NOLA, baby!' (Laissez bon temps rouler!)
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Re: Remember when we were struggling to understand the basics of the new vaccines and there was talk of a DNA vaccine before those mRNA vaccines stole the headlines...?
Posted by: sekker
Date: August 22, 2021 09:53AM
Great news.

DNA vaccines have been used for decades and safely in animals.

I’ll have to find the paper on this approach - the only negative I see is the triple dosing regime.
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