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Newly discovered biomarker predicts COVID-19 death days in advance
Posted by: p8712
Date: October 01, 2021 09:47PM
Just ask your Apple Watch to take your EKG

Quote

A retrospective investigation of health records from 140 COVID-19 patients revealed diminishing QRS waveforms were an indication of a patient declining in 74 percent of cases.

The criteria developed by the Mount Sinai team is dubbed LoQRS, and they propose it to be an effective way of triaging those patients most likely to decline. The median time to death from the first LoQRS reading detected in the study was 52 hours.

“Our study shows diminished waveforms on EKGs over the course of COVID-19 illness can be an important tool for health care workers caring for these patients, allowing them to catch rapid clinical changes over their hospital stay and intervene more quickly,” says Joshua Lampert, senior author on the new study. “With COVID-19 cases and hospitalizations continuing to rise again, EKGs may be helpful for hospitals to use when caring for these patients before their condition gets dramatically worse.”

Interestingly, the researchers also found LoQRS measures were effective in detecting those patients with influenza who were most likely to die. The median time to death from the first LoQRS measure in influenza patients, however, was around six days. The researchers point out this indicates COVID-19 is a much more virulent disease than influenza.

As LoQRS measures can only be detected over time across several EKG tests, Lambert proposes EKG measurements are taken for all COVID-19 patients when they are initially admitted.

“When it comes to caring for COVID-19 patients, our findings suggest it may be beneficial not only for health care providers to check an EKG when the patient first arrives at the hospital, but also follow-up EKGs during their hospital stay to assess for LoQRS, particularly if the patient has not made profound clinical progress,” says Lampert. “If LoQRS is present, the team may want to consider escalating medical therapy or transferring the patient to a highly monitored setting such as an intensive care unit (ICU) in anticipation of declining health.”
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Re: Newly discovered biomarker predicts COVID-19 death days in advance
Posted by: cbelt3
Date: October 02, 2021 06:15AM
FWIW it requires a 12 lead EKG and some heavy duty data analytics. It’s an interesting bit of science. Next step is looking for the point where treatment can help reverse the ventricular wall motion abnormalities.

Science is awesome.

(PDF 1 page abstract).
[www.heartrhythmjournal.com]
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Re: Newly discovered biomarker predicts COVID-19 death days in advance
Posted by: p8712
Date: October 02, 2021 11:10AM
Quote
cbelt3
FWIW it requires a 12 lead EKG and some heavy duty data analytics. It’s an interesting bit of science. Next step is looking for the point where treatment can help reverse the ventricular wall motion abnormalities.

Science is awesome.

(PDF 1 page abstract).
[www.heartrhythmjournal.com]

Yes, was joking about the Apple Watch. But honestly, it’s a much easier and quicker test than doing bloodwork.
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Re: Newly discovered biomarker predicts COVID-19 death days in advance
Posted by: Filliam H. Muffman
Date: October 02, 2021 03:06PM
It is a great start but predicting about 33% are going to die versus 25% does not seem to help that much. Even if they start advanced intervention at the very beginning, 25% of the "control group" are still dying. If they combine this with another four or five markers, I would hope to see less than 5% dying.



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