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First-Ever mRNA Vaccine for Lyme Disease Shows Promise in Guinea Pigs
Posted by: p8712
Date: November 20, 2021 11:36AM
Hoax! Chinese Lyme!

Quote

The snippets of mRNA in the vaccine code for 19 different proteins found in ticks' saliva, which will trigger the body to produce those proteins and elicit an immune reaction. By training the immune system to respond to the saliva instead of the bacteria itself, it shrinks the time that ticks spend feeding on a host; consequently, that will reduce the likelihood that the tick transmits B. burgdorferi since it takes at least 36 hours to do so, reports Live Science.

In the trial, the researchers latched Lyme-ridden ticks on two sets of guinea pigs: one that received the vaccine and the unvaccinated control group. The ticks were removed once the guinea pigs started developing inflammation or rashes, usually around 18 hours later, reports New Scientist.

The vaccinated guinea pigs developed an immune reaction, such as redness and inflammation, much faster than the non-immunized group, according to a press release.

"The vaccine enhances tick recognition, partially turning a tick bite into a mosquito bite," Fikrig says in the press release. "When you feel a mosquito bite, you swat it. With the vaccine, there is redness and likely an itch so you can recognize that you have been bitten and can pull the tick off quickly, before it has the ability to transmit B. burgdorferi."

None of the vaccinated guinea pigs contracted Lyme disease after scientists removed the ticks once inflammation began; in comparison, around half of the unvaccinated guinea pigs developed Lyme disease at that point, the press release says. This test was an important because a human would realize there was a tick and remove it once they started exhibiting symptoms.

Furthermore, if the ticks were left to fall off on their own, they let go of vaccinated guinea pigs within 48 hours, and they consumed less blood from them. On the flip side, 80 percent of the ticks on the unvaccinated group held on for more than 96 hours, allowing more time for B. burgdorferi to slip into the bloodstream, reports Live Science.

"We showed that by altering the ability of a tick to take a blood meal, you can prevent an animal from being infected with the Lyme disease agent," Fikrig tells Gizmodo.

The vaccine will go through further animal trials, such as testing in rabbits, before moving on to human trials if the results continue to show promise, writes lead author Andaleeb Sajid, a disease research at the National Institutes of Health, for the Conversation.
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Re: First-Ever mRNA Vaccine for Lyme Disease Shows Promise in Guinea Pigs
Posted by: PeterB
Date: November 20, 2021 03:59PM
Very cool.

I wonder if we'll soon be seeing mRNA-based cancer vaccines. That'd be a great thing to have.




Freya says, 'Hello from NOLA, baby!' (Laissez bon temps rouler!)
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Re: First-Ever mRNA Vaccine for Lyme Disease Shows Promise in Guinea Pigs
Posted by: mattkime
Date: November 20, 2021 05:12PM
A bike riding buddy of mine recently got Lyme Disease. Its a hazard around here. I'd love to have the protection of a vaccine.



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Re: First-Ever mRNA Vaccine for Lyme Disease Shows Promise in Guinea Pigs
Posted by: sekker
Date: November 20, 2021 05:28PM
This is a silver lining of COVID-19. RNA biotechnology companies are finally getting real investments.
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Re: First-Ever mRNA Vaccine for Lyme Disease Shows Promise in Guinea Pigs
Posted by: GGD
Date: November 22, 2021 12:57PM
I thought we were all being the Guinea Pigs for these mRNA vaccines, they're taking our jobs away and giving them to actual Guinea Pigs.
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Re: First-Ever mRNA Vaccine for Lyme Disease Shows Promise in Guinea Pigs
Posted by: Racer X
Date: November 24, 2021 12:47AM
just you wait. those guinea pigs will be losing their jobs to robot guinea pigs any day now.



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