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Bivalent booster may not have been all that...
Posted by: Tiangou
Date: January 16, 2023 10:55PM
[www.cnn.com]

Some vaccine advisers to the federal government say they’re “disappointed” and “angry” that government scientists and the pharmaceutical company Moderna didn’t present a set of infection data on the company’s new Covid-19 booster during meetings last year when the advisers discussed whether the shot should be authorized and made available to the public.

That data suggested the possibility that the updated booster might not be any more effective at preventing Covid-19 infections than the original shots...


[www.nejm.org]

Boosting with new bivalent mRNA vaccines targeting both the BA.4–BA.5 variant and the D614G strain did not elicit a discernibly superior virus-neutralizing peak antibody response as compared with boosting with the original monovalent vaccines.



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Re: Bivalent booster may not have been all that...
Posted by: RgrF
Date: January 16, 2023 11:01PM
And THAT my friends is why disinformation is so easy to disseminate.
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Re: Bivalent booster may not have been all that...
Posted by: Mr645
Date: January 17, 2023 06:25AM
All about the $$$$$$$$$
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Re: Bivalent booster may not have been all that...
Posted by: gadje
Date: January 17, 2023 06:28AM
Quote
Mr645
All about the $$$$$$$$$

Please never take another vaccine in your remaining life. Let us know how that works out for you.
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Re: Bivalent booster may not have been all that...
Posted by: Ted King
Date: January 17, 2023 08:32AM
Quote
Tiangou

[www.nejm.org]

Boosting with new bivalent mRNA vaccines targeting both the BA.4–BA.5 variant and the D614G strain did not elicit a discernibly superior virus-neutralizing peak antibody response as compared with boosting with the original monovalent vaccines.

Though that is disappointing - especially if additional data continues to indicate the same - could that still be interpreted to mean that though this supposedly tailored booster could very well not be any better than previous boosters, wouldn't receiving the booster give some protection because the previous booster you got was months ago and that protection diminishes with time? Or all kinds of boosters available now ineffective against common variants spreading now?



e pluribus unum



Edited 2 time(s). Last edit at 01/17/2023 08:37AM by Ted King.
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Re: Bivalent booster may not have been all that...
Posted by: gabester
Date: January 17, 2023 08:45AM
If I'm not mistaken, however, there are results indicating the Pfizer bivalent booster has fared better against newer covid variants, has it not? Honestly I can't keep it straight, but know that any booster is better than none, although it sounds like in this case perhaps the original Moderna booster is as good as the bivalent booster?

However, keep in mind all this study says is the newer booster only prevent infections about as well as the original but it doesn't speak to hospitalizations.



g=
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Re: Bivalent booster may not have been all that...
Posted by: cbelt3
Date: January 17, 2023 09:08AM
Virulent global pandemic that mutates very quickly. Of COURSE a vaccine won't work well. The closest comparison is influenza. And vaccines for that are complex and hard.

There is, of course, a solution.

Shut down all methods of fast transportation. Shift to horse drawn land transport and sailboats.
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Re: Bivalent booster may not have been all that...
Posted by: Ted King
Date: January 17, 2023 09:13AM
Quote
cbelt3

There is, of course, a solution.

Shut down all methods of fast transportation. Shift to horse drawn land transport and sailboats.

And barricade the roads into town with the semitrailers that you don't have the fuel to run anymore anyway. And then man the barricades with guns - lots of guns.



e pluribus unum
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Re: Bivalent booster may not have been all that...
Posted by: Mr645
Date: January 17, 2023 09:31AM
Quote
gadje
Quote
Mr645
All about the $$$$$$$$$

Please never take another vaccine in your remaining life. Let us know how that works out for you.

Typical liberal, resorts to violence, wishing harm to others.
But honestly, I took a COVID vaccine, after Trumps Operation Warpspeed allowed a safe, effective vaccine to come to market in record time, saving countless lives. But clearly with more deaths, ineffective vaccines, Biden has failed Americans, his lack of leadership allowing useless vaccines to come to market because of corrupt lobbying by the healthcare industry.
I've been through two bouts of COVID, 1st sometime prior to October 202, I tested positive for COVID-19 antibodies, months before any vaccines were out, I never knew when I was exposed. And in March of 2022, had the sniffles for 3 days, used Dayquil as a high effective treatment. I am pretty sure it was COVID, my Chinese test kits said it was but who knows.
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Re: Bivalent booster may not have been all that...
Posted by: Acer
Date: January 17, 2023 10:01AM
TIL presidents personally formulate vaccines.
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Re: Bivalent booster may not have been all that...
Posted by: gadje
Date: January 17, 2023 10:12AM
Quote
Mr645
Quote
gadje
Quote
Mr645
All about the $$$$$$$$$

Please never take another vaccine in your remaining life. Let us know how that works out for you.

Typical liberal, resorts to violence, wishing harm to others.
But honestly, I took a COVID vaccine, after Trumps Operation Warpspeed allowed a safe, effective vaccine to come to market in record time, saving countless lives. But clearly with more deaths, ineffective vaccines, Biden has failed Americans, his lack of leadership allowing useless vaccines to come to market because of corrupt lobbying by the healthcare industry.
I've been through two bouts of COVID, 1st sometime prior to October 202, I tested positive for COVID-19 antibodies, months before any vaccines were out, I never knew when I was exposed. And in March of 2022, had the sniffles for 3 days, used Dayquil as a high effective treatment. I am pretty sure it was COVID, my Chinese test kits said it was but who knows.

Where do you see violence in my post? I even used the word "please", smiley-laughing001

And you don't see violence in Trump's speect on Jan 6, 2021?
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Re: Bivalent booster may not have been all that...
Posted by: Acer
Date: January 17, 2023 10:37AM
The booster didn't make things worse, but does at least help maintain baseline resistance. Not great, but good enough to tide us over while the research continues. I'll count it as win.
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Re: Bivalent booster may not have been all that...
Posted by: Lux Interior
Date: January 17, 2023 01:41PM
Quote
Acer
TIL presidents personally formulate vaccines.

TIL that the safe, effective vaccine the Trump formulated was suddenly ineffective when Biden became president.
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Re: Bivalent booster may not have been all that...
Posted by: Mr645
Date: January 17, 2023 02:02PM
Quote
Acer
The booster didn't make things worse, but does at least help maintain baseline resistance. Not great, but good enough to tide us over while the research continues. I'll count it as win.

In England they concluded that the Bivalent vaccine made COVID XBB worse, because those naturally infected by Omicron did much better fighting off XBB. Read from John Campbell on Youtube
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Re: Bivalent booster may not have been all that...
Posted by: mattkime
Date: January 17, 2023 02:40PM
Quote
Mr645
Quote
Acer
The booster didn't make things worse, but does at least help maintain baseline resistance. Not great, but good enough to tide us over while the research continues. I'll count it as win.

In England they concluded that the Bivalent vaccine made COVID XBB worse, because those naturally infected by Omicron did much better fighting off XBB. Read from John Campbell on Youtube

Ah, you're pointing us toward your universe of alternative facts.

>He has been criticised for suggesting COVID-19 deaths have been over-counted, repeating false claims about the use of ivermectin as a COVID-19 treatment, and providing misleading commentary about the safety of COVID-19 vaccines.



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Re: Bivalent booster may not have been all that...
Posted by: AllGold
Date: January 17, 2023 02:52PM
Whatever. I was due for a booster anyway.
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Re: Bivalent booster may not have been all that...
Posted by: gadje
Date: January 17, 2023 03:55PM
John Lorimer Campbell is an English YouTuber and retired nurse educator known for his videos regarding the COVID-19 pandemic. His videos received praise early in the pandemic, but later veered into misinformation.[2] He has been criticised for suggesting COVID-19 deaths have been over-counted, repeating false claims about the use of ivermectin as a COVID-19 treatment, and providing misleading commentary about the safety of COVID-19 vaccines.[3][4][5] As of December 2022, his YouTube channel had 2.6 million subscribers and over 581 million views.
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Re: Bivalent booster may not have been all that...
Posted by: AllGold
Date: January 17, 2023 04:04PM
Quote
Mr645
Quote
gadje
Quote
Mr645
All about the $$$$$$$$$

Please never take another vaccine in your remaining life. Let us know how that works out for you.

Typical liberal, resorts to violence, wishing harm to others.
But honestly, I took a COVID vaccine, after Trumps Operation Warpspeed allowed a safe, effective vaccine to come to market in record time, saving countless lives. But clearly with more deaths, ineffective vaccines, Biden has failed Americans, his lack of leadership allowing useless vaccines to come to market because of corrupt lobbying by the healthcare industry.

It's almost adorable how you don't see your own bias.

The same exact vaccines that were "perfect" and "beautiful" under Trump are now horrible under Biden. Again, the same exact vaccines.
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Re: Bivalent booster may not have been all that...
Posted by: mattkime
Date: January 17, 2023 04:24PM
Quote
AllGold
The same exact vaccines that were "perfect" and "beautiful" under Trump are now horrible under Biden. Again, the same exact vaccines.

At this point I'm out of words for this sort of thing. Its more than I can address in a couple of sentences.



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Re: Bivalent booster may not have been all that...
Posted by: Mr645
Date: January 17, 2023 04:27PM
Quote
AllGold
Quote
Mr645
Quote
gadje
Quote
Mr645
All about the $$$$$$$$$

Please never take another vaccine in your remaining life. Let us know how that works out for you.

Typical liberal, resorts to violence, wishing harm to others.
But honestly, I took a COVID vaccine, after Trumps Operation Warpspeed allowed a safe, effective vaccine to come to market in record time, saving countless lives. But clearly with more deaths, ineffective vaccines, Biden has failed Americans, his lack of leadership allowing useless vaccines to come to market because of corrupt lobbying by the healthcare industry.



It's almost adorable how you don't see your own bias.

The same exact vaccines that were "perfect" and "beautiful" under Trump are now horrible under Biden. Again, the same exact vaccines.

The first vaccines were tested, they worked, this latest version bypassed testing and does not work.
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Re: Bivalent booster may not have been all that...
Posted by: RgrF
Date: January 17, 2023 04:55PM
Believers don't need facts.
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Re: Bivalent booster may not have been all that...
Posted by: sekker
Date: January 17, 2023 05:52PM
Quote
Mr645
Quote
AllGold
Quote
Mr645
Quote
gadje
Quote
Mr645
All about the $$$$$$$$$

Please never take another vaccine in your remaining life. Let us know how that works out for you.

Typical liberal, resorts to violence, wishing harm to others.
But honestly, I took a COVID vaccine, after Trumps Operation Warpspeed allowed a safe, effective vaccine to come to market in record time, saving countless lives. But clearly with more deaths, ineffective vaccines, Biden has failed Americans, his lack of leadership allowing useless vaccines to come to market because of corrupt lobbying by the healthcare industry.



It's almost adorable how you don't see your own bias.

The same exact vaccines that were "perfect" and "beautiful" under Trump are now horrible under Biden. Again, the same exact vaccines.

The first vaccines were tested, they worked, this latest version bypassed testing and does not work.

No, the bivalent vaccines DO work. They may or may not be any better than the first vaccines.

My understanding from some top experts I follow is that bivalent boosters ARE being shown to be better against more recent variants.

Regardless, get your booster if you want to greatly reduce your risk of being sent to the hospital (or worse) when you next get COVID.
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Re: Bivalent booster may not have been all that...
Posted by: Tiangou
Date: January 17, 2023 05:56PM
Quote
Mr645
The first vaccines were tested, they worked, this latest version bypassed testing and does not work.

No.

That's completely wrong. It's illogical. You're injecting a spurious supposition for a conclusion that is not derivable from any facts at hand.

Moderna failed to produce some of their results when the FDA asked for supporting data. That doesn't imply in any way that testing was "bypassed." The FDA's process did not rely on that missing data.

The bivalent vaccine appears to be roughly on-par with the original vaccine for preventing and moderating infection/symptoms. It works fine. It just doesn't work better.







Edited 2 time(s). Last edit at 01/17/2023 06:00PM by Tiangou.
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Re: Bivalent booster may not have been all that...
Posted by: gadje
Date: January 17, 2023 06:16PM
Does anyone here think Mr645 will ever admit he is biased, wrong, etc?
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Re: Bivalent booster may not have been all that...
Posted by: Speedy
Date: January 17, 2023 11:20PM
Paxlovid saved Trump’s life, not a vaccine.



Saint Cloud, Minnesota, where the weather is wonderful even when it isn't.
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Re: Bivalent booster may not have been all that...
Posted by: N-OS X-tasy!
Date: January 18, 2023 12:58AM
Quote
gadje
Does anyone here think Mr645 will ever admit he is biased, wrong, etc?

…insane…



It is what it is.
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Re: Bivalent booster may not have been all that...
Posted by: anonymouse1
Date: January 18, 2023 04:07AM
1. Bonus points for linking to a legitimate scientific article in NEJM!
2. From that article " Limitations of our study include the small sample size and follow-up period of our groups. We also note that the between-group comparisons were not controlled for factors such as age, vaccine type, and health status, which may have had an effect on antibody responses.'
3. The potentially fatal flaw is that they don't segregate out those in the study who may have been actually infected with COVID, of any variety. There are some indications of that data in the appendix, but not in the letter itself For me, that's a big deal.

Quote
Tiangou
[www.cnn.com]

Some vaccine advisers to the federal government say they’re “disappointed” and “angry” that government scientists and the pharmaceutical company Moderna didn’t present a set of infection data on the company’s new Covid-19 booster during meetings last year when the advisers discussed whether the shot should be authorized and made available to the public.

That data suggested the possibility that the updated booster might not be any more effective at preventing Covid-19 infections than the original shots...


[www.nejm.org]

Boosting with new bivalent mRNA vaccines targeting both the BA.4–BA.5 variant and the D614G strain did not elicit a discernibly superior virus-neutralizing peak antibody response as compared with boosting with the original monovalent vaccines.
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Re: Bivalent booster may not have been all that...
Posted by: anonymouse1
Date: January 18, 2023 04:11AM
That's a horrible mis-description. All that really changed is the addition of protection against ANOTHER spike protein. At a bare minimum, we already know that the elements of the vaccine targeting the original spike protein work. Whether it works better than the original seems up for discussion.

Quote
Mr645
Quote
AllGold
Quote
Mr645
Quote
gadje
Quote
Mr645
All about the $$$$$$$$$

Please never take another vaccine in your remaining life. Let us know how that works out for you.

Typical liberal, resorts to violence, wishing harm to others.
But honestly, I took a COVID vaccine, after Trumps Operation Warpspeed allowed a safe, effective vaccine to come to market in record time, saving countless lives. But clearly with more deaths, ineffective vaccines, Biden has failed Americans, his lack of leadership allowing useless vaccines to come to market because of corrupt lobbying by the healthcare industry.



It's almost adorable how you don't see your own bias.

The same exact vaccines that were "perfect" and "beautiful" under Trump are now horrible under Biden. Again, the same exact vaccines.

The first vaccines were tested, they worked, this latest version bypassed testing and does not work.
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Re: Bivalent booster may not have been all that...
Posted by: Tiangou
Date: January 18, 2023 05:56AM
Another few items of note:

The FDA Vaccines Advisory Committee meets again on Jan 26th to come up with recommendations for the next booster. There's some talk that they may be leaning towards a trivalent booster.

Only about 15% of the country got the bivalent booster.

The price of the Moderna vaccine is going up to $130 per dose and Congress has not authorized new funding for it.

In the United States, more than 550 people are dying every day of COVID in the current surge.



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Re: Bivalent booster may not have been all that...
Posted by: Grateful11
Date: January 18, 2023 09:50AM
I got the latest Pfizer booster last week.



Grateful11
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Re: Bivalent booster may not have been all that...
Posted by: mattkime
Date: January 18, 2023 10:06AM
Quote
Grateful11
I got the latest Pfizer booster last week.

Huh, its interesting that they're still in the game.
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Re: Bivalent booster may not have been all that...
Posted by: Mr645
Date: January 18, 2023 11:14AM
[www.reuters.com]
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Re: Bivalent booster may not have been all that...
Posted by: decay
Date: January 18, 2023 11:38AM
please don't refer any YouTube 'experts' as reliable information regarding vaccines.



---
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Re: Bivalent booster may not have been all that...
Posted by: DeusxMac
Date: January 18, 2023 11:58AM
Quote
Mr645
But clearly with more deaths, ineffective vaccines, Biden has failed Americans, his lack of leadership allowing useless vaccines to come to market because of corrupt lobbying by the healthcare industry.

Quote
Mr645
[www.reuters.com]

You're not ACTUALLY reading your links are you?

"Statistics that show the majority of deaths from COVID-19 are among vaccinated people reflect the fact most people are vaccinated, not that the vaccines are ineffective, as implied in a social media post. "

Or is it that you just have reading comprehension problems?
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Re: Bivalent booster may not have been all that...
Posted by: mattkime
Date: January 18, 2023 12:07PM
At this point if you even die from a car crash you can assume there's an antivaxxer counting you as a vaccine related death. Hopefully they'll soon grow bored and find new hobbies.



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Re: Bivalent booster may not have been all that...
Posted by: JoeH
Date: January 18, 2023 12:24PM
Quote
DeusxMac
Quote
Mr645
But clearly with more deaths, ineffective vaccines, Biden has failed Americans, his lack of leadership allowing useless vaccines to come to market because of corrupt lobbying by the healthcare industry.

Quote
Mr645
[www.reuters.com]

You're not ACTUALLY reading your links are you?

"Statistics that show the majority of deaths from COVID-19 are among vaccinated people reflect the fact most people are vaccinated, not that the vaccines are ineffective, as implied in a social media post. "

Or is it that you just have reading comprehension problems?

Reading comprehension, and almost total failure to recognize he has trotted out almost every one of these arguments in the past and shown to be absolutely wrong.
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Re: Bivalent booster may not have been all that...
Posted by: Lux Interior
Date: January 18, 2023 01:49PM
Quote
gadje
Does anyone here think Mr645 will ever admit he is biased, wrong, etc?

S/He's just filling the vacuum left by Swampy.
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Re: Bivalent booster may not have been all that...
Posted by: PeterB
Date: January 18, 2023 03:14PM
Quote
mattkime
Quote
AllGold
The same exact vaccines that were "perfect" and "beautiful" under Trump are now horrible under Biden. Again, the same exact vaccines.

At this point I'm out of words for this sort of thing. Its more than I can address in a couple of sentences.

Excellent exercise in doublethink. It's OK (even "great!") if one person does something, it's terrible if someone else does the exact same thing. Or if one person does something truly egregious, it's perfectly OK, but if another person does something a little similar, but nowhere near as egregious, that person has to be tarred and feathered. I think we're all now observing this doublethink at work in other contexts, particularly ones involving classified documents. grinning smiley




Freya says, 'Hello from NOLA, baby!' (Laissez bon temps rouler!)
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Re: Bivalent booster may not have been all that...
Posted by: Grateful11
Date: January 18, 2023 09:26PM
Quote
mattkime
At this point if you even die from a car crash you can assume there's an antivaxxer counting you as a vaccine related death. Hopefully they'll soon grow bored and find new hobbies.

The one that gets me is the Covid deniers that if their relative dies with Covid, not from Covid, they get us taxpayers to pay for the funeral. I know of one such case, they died of old age but because they tested positive 3 days before they died we paid for the funeral. I know and they know this person didn't die from Covid.



Grateful11
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